王伟林,男,理学博士,研究生学历,大连海洋大学副教授。
主要从事海洋无脊椎动物免疫学研究,聚焦软体动物的免疫适应性与进化,综合应用分子生物学、细胞生物学、免疫学及生物信息学等方法手段,解析养殖贝类免疫记忆及内稳态维持的机制,探究海洋无脊椎动物免疫防御的特征及进化。作为主要成员,承担科研项目7项,其中国家级项目5项;共发表SCI收录论文60余篇,其中第一/通讯作者文章14篇,申请发明专利5项。协助指导硕士研究生、博士研究生10余人,其中多人获校优秀毕业生荣誉称号。
2008/09-2012/06 | 宁波大学海洋学院 | 生物技术专业 | 本科 | 学士 |
2012/09-2017/08 | 中国科学院海洋研究所 | 海洋生物学专业 | 研究生 | 博士 |
2017.12-2019.12 | 大连海洋大学 | 助理研究员 |
2020.01-至今 | 大连海洋大学 | 副教授 |
序号 | 论文、专著名称 | 学术期刊或出版社名称 | 发表(出版)年份 | 论文 | 作(著)者 |
1 | The Involvement of TLR Signaling and Anti-Bacterial Effectors in Enhanced Immune Protection of Oysters after Vibrio Splendidus Pre-Exposure. | Developmental and Comparative Immunology | 2020 | SCI | 1 |
2 | The Sensing Pattern and Antitoxic Response of Crassostrea Gigas against Extracellular Products of Vibrio Splendidus. | Developmental and Comparative Immunology | 2020 | SCI | 1 |
3 | The Lectin Domain Containing Proteins with Mucosal Immunity and Digestive Functions in Oyster Crassostrea Gigas. | Fish & Shellfish Immunology | 2019 | SCI | 1 |
4 | ATG10 (Autophagy-Related 10) Regulates the Formation of Autophagosome in the Anti-Virus Immune Response of Pacific Oyster (Crassostrea Gigas). | Fish & Shellfish Immunology | 2019 | SCI | 2 |
5 | Pathogen-Derived Carbohydrate Recognition in Molluscs Immune Defense. | International Journal of Molecular Sciences | 2018 | SCI | 1 |
6 | The Granulocytes Are the Main Immunocompetent Hemocytes in Crassostrea Gigas. | Developmental and Comparative Immunology | 2017 | SCI | 1 |
7 | A New Non-Phagocytic TLR6 with Broad Recognition Ligands from Pacific Oyster Crassostrea Gigas. | Developmental and Comparative Immunology | 2016 | SCI | 1 |
8 | A Novel Phagocytic Receptor (CgNimC) from Pacific Oyster Crassostrea Gigas with Lipopolysaccharide and Gram-Negative Bacteria Binding Activity. | Fish & Shellfish Immunology | 2015 | SCI | 1 |
9 | The Members of the Highly Diverse Crassostrea Gigas Integrin Family Cooperate for the Generation of Various Immune Responses | Frontiers in Immunology | 2020 | SCI | 3 |
10 | An Activating Transcription Factor 6 Beta (ATF6β) Regulates Apoptosis of Hemocyte during Immune Response in Crassostrea Gigas. | Fish & Shellfish Immunology | 2020 | SCI | 2 |
11 | A Novel Programmed Cell Death Protein 4 Negatively Regulates CgIL17-5 Expression in Hemocytes of Oyster Pacific Oyster (Crassostrea Gigas). | Fish & Shellfish Immunology | 2020 | SCI | 2 |
12 | The Dicer from Oyster Crassostrea Gigas Functions as an Intracellular Recognition Molecule and Effector in Anti-Viral Immunity. | Fish & Shellfish Immunology | 2019 | SCI | 2 |
13 | 17. Wang, Lingling, Wang, Weilin, Chuanyan Yang, Jiejie Sun, and Linsheng Song. 2019. “The Immune Recognition Mechanisms in Mollucs.” 91: 461–62. | Fish & Shellfish Immunology | 2019 | SCI | 2 |
14 | The Enhanced Immune Protection in Chinese Mitten Crab Eriocheir Sinensis Against the Second Exposure to Bacteria Aeromonas Hydrophila. | Frontiers in Immunology | 2019 | SCI | 3 |
15 | The Immunomodulatory Function of Invertebrate Specific Neuropeptide FMRFamide in Oyster Crassostrea Gigas. | Fish & Shellfish Immunology | 2019 | SCI | 3 |
16 | CgAATase with Specific Expression Pattern Can Be Used as a Potential Surface Marker for Oyster Granulocytes. | Fish & Shellfish Immunology | 2019 | SCI | 4 |
17 | A SPRY Domain-Containing SOCS Box Protein 3 (SPSB3) Involved in the Regulation of Cytokine Production in Granulocytes of Crassostrea Gigas. | Developmental and Comparative Immunology | 2019 | SCI | 3 |
18 | A Novel Caspase-Associated Recruitment Domain (CARD) Containing Protein (CgCARDCP-1) Involved in LPS Recognition and NF-ΚB Activation in Oyster (Crassostrea Gigas). | Fish & Shellfish Immunology | 2018 | SCI | 3 |
19 | A DM9-Containing Protein from Oyster Crassostrea Gigas (CgDM9CP-2) Serves as a Multipotent Pattern Recognition Receptor. | Developmental and Comparative Immunology | 2018 | SCI | 3 |
20 | A GTP-Dependent Phosphoenolpyruvate Carboxykinase from Crassostrea Gigas Involved in Immune Recognition. | Developmental and Comparative Immunology | 2017 | SCI | 3 |
21 | Glycogen Synthase Kinase-3 (GSK3) Regulates TNF Production and Haemocyte Phagocytosis in the Immune Response of Chinese Mitten Crab Eriocheir Sinensis. | Developmental and Comparative Immunology | 2017 | SCI | 3 |
22 | The Hematopoiesis in Gill and Its Role in the Immune Response of Pacific Oyster Crassostrea Gigas against Secondary Challenge with Vibrio Splendidus. | Developmental and Comparative Immunology | 2017 | SCI | 3 |
23 | Identification and Functional Analysis of a Novel IFN-like Protein (CgIFNLP) in Crassostrea Gigas. | Fish & Shellfish Immunology | 2015 | SCI | 3 |
在读人数 | 已毕业人数 |
序号 | 项目名称 | 项目来源 | 起止年月 | 经费 | 主持/参加 | 完成情况 |
1 | 长牡蛎三类血细胞免疫功能及分子特征的初步探究 | 国家自然科学基金 | 2019-01-01到2021-12-31 | 28 | 主持 | 在研 |
2 | 长牡蛎应对灿烂弧菌胞外产物毒性的免疫应答反应 | 省部级实验室(平台)开放课题 | 2018-01-01到2019-12-31 | 3 | 主持 | 完成 |
3 | 中华绒螯蟹GATA转录因子及其磷酸化修饰对造血过程的调控作用 | 国家自然科学基金 | 2019-01-01到2021-12-31 | 26 | 参加 | 在研 |
4 | 去甲肾上腺素调节长牡蛎颗粒细胞合成肿瘤坏死因子的机制研究 | 国家自然科学基金 | 2019-01-01到2021-12-31 | 26 | 参加 | 在研 |
5 | 长牡蛎C-型凝集素调控炎症因子表达的机制研究 | 国家自然科学基金 | 2019-01-01到2021-12-31 | 27 | 参加 | 在研 |
6 | 针对不同靶点的刺参凝集素筛选及其分子机制研究 | 市科技计划 | 2018-01-01到2019-12-31 | 10 | 参加 | 完成 |
7 | 牡蛎夏季病害发生及生态免疫防治机理研究 | 国家自然科学基金 | 2018-01-01到2021-12-31 | 280 | 参加 | 在研 |
序号 | 专利名称 | 授权专利号 | 年份 | 专利类别 | 本人排名 |
1 | 可增强长牡蛎免疫应答的重组血清淀粉样蛋白A及制备方法 | 201911211145.5 | 2019 | 发明 | 2 |
2 | 可抑制灿烂弧菌胞外产物毒性的CgTIMP重组蛋白及制备方法 | 201911211268.9 | 2019 | 发明 | 2 |
3 | 长牡蛎含DM9结构域蛋白CgDM9CP-2、制备方法及应用 | 201711418771.2 | 2017 | 发明 | 3 |
4 | 数字PCR检测长牡蛎白细胞介素17-5基因表达量的引物及探针 | 201910813289.1 | 2019 | 发明 | 3 |
5 | 长牡蛎颗粒细胞标记分子AATase单克隆抗体的制备及应用 | 201811323058.4 | 2018 | 发明 | 4 |