王伟林

职务:

职称:副教授

联系电话:18018985437

电子信箱:wangweilin@dlou.edu.cn

硕士生导师:

海洋科学

所属教研室:

海洋科学专业教研室

个人简介Personal Profile

王伟林,男,理学博士,研究生学历,大连海洋大学副教授。

主要从事海洋无脊椎动物免疫学研究,聚焦软体动物的免疫适应性与进化,综合应用分子生物学、细胞生物学、免疫学及生物信息学等方法手段,解析养殖贝类免疫记忆及内稳态维持的机制,探究海洋无脊椎动物免疫防御的特征及进化。作为主要成员,承担科研项目7项,其中国家级项目5项;共发表SCI收录论文60余篇,其中第一/通讯作者文章14篇,申请发明专利5项。协助指导硕士研究生、博士研究生10余人,其中多人获校优秀毕业生荣誉称号。


学习经历Learning Experiences
2008/09-2012/06宁波大学海洋学院生物技术专业本科学士
2012/09-2017/08中国科学院海洋研究所海洋生物学专业研究生博士
工作经历Work Experiences
2017.12-2019.12大连海洋大学助理研究员
2020.01-至今大连海洋大学副教授
论文专著Thesis Monographs

序号

论文、专著名称

学术期刊或出版社名称

发表(出版)年份

论文
检索情况

(著)者
名次

1

The Involvement of TLR Signaling and Anti-Bacterial Effectors in Enhanced Immune Protection of Oysters after Vibrio Splendidus Pre-Exposure.

Developmental and Comparative Immunology

2020

SCI

1

2

The Sensing Pattern and Antitoxic Response of Crassostrea Gigas against Extracellular Products of Vibrio Splendidus.

Developmental and Comparative Immunology

2020

SCI

1

3

The Lectin Domain Containing Proteins with Mucosal Immunity and Digestive Functions in Oyster Crassostrea Gigas.

Fish & Shellfish Immunology

2019

SCI

1

4

ATG10 (Autophagy-Related 10) Regulates the Formation of Autophagosome in the Anti-Virus Immune Response of Pacific Oyster (Crassostrea Gigas).

Fish & Shellfish Immunology

2019

SCI

2

5

Pathogen-Derived Carbohydrate Recognition in Molluscs Immune Defense.

International Journal of Molecular Sciences

2018

SCI

1

6

The Granulocytes Are the Main Immunocompetent Hemocytes in Crassostrea Gigas.

Developmental and Comparative Immunology

2017

SCI

1

7

A New Non-Phagocytic TLR6 with Broad Recognition Ligands from Pacific Oyster Crassostrea Gigas.

Developmental and Comparative Immunology

2016

SCI

1

8

A Novel Phagocytic Receptor (CgNimC) from Pacific Oyster Crassostrea Gigas with Lipopolysaccharide and Gram-Negative Bacteria Binding Activity.

Fish & Shellfish Immunology

2015

SCI

1

9

The Members of the Highly Diverse Crassostrea Gigas Integrin Family Cooperate for the Generation of Various Immune Responses

Frontiers in Immunology

2020

SCI

3

10

An Activating Transcription Factor 6 Beta (ATF6β) Regulates Apoptosis of Hemocyte during Immune Response in Crassostrea Gigas.

Fish & Shellfish Immunology

2020

SCI

2

11

A Novel Programmed Cell Death Protein 4 Negatively Regulates CgIL17-5 Expression in Hemocytes of Oyster Pacific Oyster (Crassostrea Gigas).

Fish & Shellfish Immunology

2020

SCI

2

12

The Dicer from Oyster Crassostrea Gigas Functions as an Intracellular Recognition Molecule and Effector in Anti-Viral Immunity.

Fish & Shellfish Immunology

2019

SCI

2

13

17. Wang, Lingling, Wang, Weilin, Chuanyan Yang, Jiejie Sun, and Linsheng Song. 2019. “The Immune Recognition Mechanisms in Mollucs.” 91: 461–62.

Fish & Shellfish Immunology

2019

SCI

2

14

The Enhanced Immune Protection in Chinese Mitten Crab Eriocheir Sinensis Against the Second Exposure to Bacteria Aeromonas Hydrophila.

Frontiers in Immunology

2019

SCI

3

15

The Immunomodulatory Function of Invertebrate Specific Neuropeptide FMRFamide in Oyster Crassostrea Gigas.

Fish & Shellfish Immunology

2019

SCI

3

16

CgAATase with Specific Expression Pattern Can Be Used as a Potential Surface Marker for Oyster Granulocytes.

Fish & Shellfish Immunology

2019

SCI

4

17

A SPRY Domain-Containing SOCS Box Protein 3 (SPSB3) Involved in the Regulation of Cytokine Production in Granulocytes of Crassostrea Gigas.

Developmental and Comparative Immunology

2019

SCI

3

18

A Novel Caspase-Associated Recruitment Domain (CARD) Containing Protein (CgCARDCP-1) Involved in LPS Recognition and NF-ΚB Activation in Oyster (Crassostrea Gigas).

Fish & Shellfish Immunology

2018

SCI

3

19

A DM9-Containing Protein from Oyster Crassostrea Gigas (CgDM9CP-2) Serves as a Multipotent Pattern Recognition Receptor.

Developmental and Comparative Immunology

2018

SCI

3

20

A GTP-Dependent Phosphoenolpyruvate Carboxykinase from Crassostrea Gigas Involved in Immune Recognition.

Developmental and Comparative Immunology

2017

SCI

3

21

Glycogen Synthase Kinase-3 (GSK3) Regulates TNF Production and Haemocyte Phagocytosis in the Immune Response of Chinese Mitten Crab Eriocheir Sinensis.

Developmental and Comparative Immunology

2017

SCI

3

22

The Hematopoiesis in Gill and Its Role in the Immune Response of Pacific Oyster Crassostrea Gigas against Secondary Challenge with Vibrio Splendidus.

Developmental and Comparative Immunology

2017

SCI

3

23

Identification and Functional Analysis of a Novel IFN-like Protein (CgIFNLP) in Crassostrea Gigas.

Fish & Shellfish Immunology

2015

SCI

3

指导研究生情况Mentoring graduate students

在读人数


已毕业人数

项目信息Project Information

序号

项目名称

项目来源

起止年月

经费
(万元)

主持/参加

完成情况

1

长牡蛎三类血细胞免疫功能及分子特征的初步探究

国家自然科学基金

2019-01-01到2021-12-31

28

主持

在研

2

长牡蛎应对灿烂弧菌胞外产物毒性的免疫应答反应

省部级实验室(平台)开放课题

2018-01-01到2019-12-31

3

主持

完成

3

中华绒螯蟹GATA转录因子及其磷酸化修饰对造血过程的调控作用

国家自然科学基金

2019-01-01到2021-12-31

26

参加

在研

4

去甲肾上腺素调节长牡蛎颗粒细胞合成肿瘤坏死因子的机制研究

国家自然科学基金

2019-01-01到2021-12-31

26

参加

在研

5

长牡蛎C-型凝集素调控炎症因子表达的机制研究

国家自然科学基金

2019-01-01到2021-12-31

27

参加

在研

6

针对不同靶点的刺参凝集素筛选及其分子机制研究

市科技计划

2018-01-01到2019-12-31

10

参加

完成

7

牡蛎夏季病害发生及生态免疫防治机理研究

国家自然科学基金

2018-01-01到2021-12-31

280

参加

在研

专利和获奖信息Patent and Award Information

序号

专利名称

授权专利号

年份

专利类别
(发明/实用新型)

本人排名

1

可增强长牡蛎免疫应答的重组血清淀粉样蛋白A及制备方法

201911211145.5

2019

发明

2

2

可抑制灿烂弧菌胞外产物毒性的CgTIMP重组蛋白及制备方法

201911211268.9

2019

发明

2

3

长牡蛎含DM9结构域蛋白CgDM9CP-2、制备方法及应用

201711418771.2

2017

发明

3

4

数字PCR检测长牡蛎白细胞介素17-5基因表达量的引物及探针

201910813289.1

2019

发明

3

5

长牡蛎颗粒细胞标记分子AATase单克隆抗体的制备及应用

201811323058.4

2018

发明

4